4-Aco DMT


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What is 4-Aco DMT

O-Acetylpsilocin (also known as psilacetin4-acetoxy-DMT, or 4-AcO-DMT]) is a semi-synthetic psychoactive drug that has been suggested by David Nichols to be a potentially useful alternative to psilocybin] for pharmacological studies, as they are both believed to be prodrugs of psilocin. [. However, some users report that O-acetylpsilocin’s subjective effects differ from those of psilocybin and psilocin. It is the acetylated form of the psilocybin mushroom alkaloid psilocin and is a lower homolog of 4-AcO-MET, 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT,also and alternative definition could be,

4-Acetoxy-N,N-dimethyltryptamine  is a novel psychedelic substance of the tryptamine class. It is a structural analog of psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). Like psilocybin, it is thought to produce its effects primarily by binding to serotonin receptors in the brain; however, the precise mechanism is not fully understood.


The synthesis of 4-AcO-DMT was first reported in 1963 by Albert Hofmann and Franz Troxler as part of an investigation into psilocin analogs. However, its pharmacology and subjective effects were not explored. A paper authored by David E. Nichols in 1999 proposed it as a potentially useful alternative to psilocybin for pharmacological research due to lower cost of synthesis. Reports of recreational use began to surface shortly after its appearance on the online research chemical market in the 2010s.

Most people buy psilacetin as a brown or off-white powder that can be mixed with water just prior to dosing. But it’s also available in pills, tablets, capsules, and gel tabs among other preparations.

True to its nickname, “synthetic mushrooms”, a 4-AcO-DMT experience is similar to a psilocybin trip. Its effects are dose-dependent, but mystical-type experiences are common, as are philosophical insights and a sense of empathic well-being.


Subjective effects are reported to be nearly identical to those of psilocybin mushrooms and include geometric visual hallucinations, time distortion, enhanced introspection, euphoria, and ego loss. 4-acetoxy-DMT is theorized to act as a prodrug to psilocin in a similar manner as psilocybin, which may account for this similarity. 4-AcO-DMT’s classical psychedelic effects and favorable tolerability profile has led it to become popular among novel psychoactive substance users who seek mystical or entheogenic experiences.

Very little data exists on the pharmacology, metabolism, and toxicity of 4-acetoxy-DMT. While it is believed to have a favorable safety profile similar to that of psilocybin mushrooms (which are known to be physiologically non-toxic) there is currently no data to support this claim. It is highly advised to use harm reduction practices if using this substance.


Like psilocybin (4-PO-DMT), 4-AcO-DMT is an ester of psilocin (4-HO-DMT). The difference between the two is that psilocybin is the O-phosphorylated form, which naturally occurs in mushrooms; 4-acetoxy-DMT, on the other hand, is the O-acetylated form, hence the name O-Acetylpsilocin. In other words, 4-acetoxy-DMT has the same basic structure as both psilocin and psilocybin, but with an acetoxy group bonded to its indole ring. 4 aco dmt for sale

Receptor binding

Very little data exist on the receptor binding and metabolism of 4-acetoxy-DMT. Like psilocybin, it’s thought to be a prodrug of psilocin—in this case, deacetylated to psilocin during first-pass metabolism by the stomach and liver. With this in mind, we can assume that 4-AcO-DMT activates the 5-HT2A serotonin receptors, which is a similar mechanism of action as psilocybin and many other psychedelics.

However, some people have come to believe that 4-AcO-DMT may be more than just a prodrug of psilocin. There are many anecdotal reports of people injecting or smoking 4-acetoxy-DMT and experiencing nearly immediate psychoactivity (i.e. when bypassing first-pass metabolism). This suggests it may have its own pharmacodynamic profile and could account for some of the differences between the psilocybin and 4-acetoxy-DMT experiences. That said, it’s worth noting that naturally occurring psilocybin tends to be accompanied by other alkaloids that have their own effects, such as baeocystin and norbaeocystin—neither of which are present in 4-AcO-DMT powders. 4 aco dmt for sale, 4 aco dmt buy

Safety and toxicity

Taking into account the pharmacological similarities, we can assume that its just as safe and non-addictive as psilocybin/psilocin. Although clinical research is lacking—especially into its long-term effects and toxic overdose (if any)—anecdotal reports support its presumed safety. However, a number of 4-acetoxy-DMT trip reports report that very high doses can cause blackouts, vomiting, heart problems, hypertension, and seizures.  No fatalities have been reported—at least in the absence of other drugs.


4-AcO-DMT is usually sold as a fumarate salt (a white-ish powder) containing on average 1 mg of pure 4-AcO-DMT for every 1.24 mg of powder. If it’s a hydrochloride salt, it will contain on average 1 mg of pure 4-acetoxy-DMT for every 1.15 mg of powder. In practice, the difference may be negligible, but it’s worth knowing. Given the prevalence of 4-AcO-DMT fumarate—and the fact that it contains less of the active indole alkaloid—it’s safe to assume dosage guidelines found online refer to the fumarate salt.

As a powder, it is usually taken orally, but it can also be taken intranasally (snorted/insufflated). For other methods see FAQ. Either way, it’s processed more rapidly by the body than psilocybin mushrooms, typically resulting in a faster, more intense onset.

Even high-end doses are tiny, as with DMT, so you’ll need a digital milligram scale to weigh out your desired amount, based on the following ranges:.

Oral 4-AcO-DMT dosage (in mg)


  • Threshold: 2.5 – 5
  • Light: 5 – 10
  • Common: 10 – 25
  • Strong: 25 – 40
  • Heavy: 40+

Intranasal 4-AcO-DMT dosage (in mg)

  • Threshold: <5
  • Light: 5 – 10
  • Common: 10 – 20
  • Strong: 20 – 30
  • Heavy: 30+
  • 4 aco dmt for sale

Additional information


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